National Nanotechnology Coordination Office Announces a Public Meeting

Today's Federal Register carries a notice of a public meeting on Tuesday March 30th and Wednesday March 31st 2010 to be held at the Holiday Inn Rosslyn-Key Bridge in Arlington Virginia .

The meeting will be a workshop designed "to provide an open forum to discuss the state-of-the-art of the science related to environmental, health, and safety aspects of nanomaterials
in two areas: Risk Management Methods and Ethical, Legal, and Societal
Implications (ELSI) of Nanotechnology."

Registration is required to attend the workshop and information on how to register is available in the notice. Anyone wishing to present 3-5 minutes of public comments also needs to register. Written or electronic comments must be submitted via e-mail at capstone@nnco.nano.gov until April 30, 2010. Written comments can also be mailed to Capstone Workshop, c/o NNCO,
4201 Wilson Blvd., Stafford II, Suite 405, Arlington, VA 22230.
 

Those unable to attend the workshop in person can view the main sessions via webcast. The draft agenda for the workshop is below. Among the invited speakers and guest is John Monica, a partner in Porter Wright's DC office. Further information about the workshop is available on the National Nanotechnology Initiative website.

Schedule and Agenda

Draft Agenda (2/25/10):

Tuesday, March 30

7:30 a.m. Registration and Continental Breakfast

8:30 a.m. Morning Introductory Session:
-Welcome

-Opening Remarks

- Highlights from previous workshops

- Introduction to Risk Management Methods:
Gary Marchant, Arizona State University
Greg Lowry, Carnegie Mellon University

- Introduction to Ethical, Legal, and Societal Implications of Nanotechnology
Pilar Ossorio, University of Wisconsin, Madison
Barbara Herr-Harthorn, University of California, Santa Barbara

- Interactive audience participation

Afternoon Session:
- Concurrent Breakout Sessions
I. - III. Risk Management Research Needs
IV. - VI. Ethical, Legal, and Societal Implications

- Closing Session for first day
Tom Kalil, White House Office of Science & Technology Policy
 

5:30 Adjourn

Wednesday, March 31

7:30 a.m. Registration and Continental Breakfast

8:00 a.m. Morning Session:
- Report Outs from Breakout Sessions

- Composite Case Study
Panelists including:
Carolyn Cairns, Consumers Union
John Monica, Porter, Wright, Arthur, & Morris, LLP
Thomas Seager, Rochester Institute of Technology

- Concurrent Breakout Sessions

-Public Comment Period

Working Lunch

Afternoon Session:
- Discussion: "Challenges facing Risk Management Methods and Ethical, Legal, and Societal Implications"
- Closing Session: "Grand Challenges for nanoEHS research"

4:00 p.m. Adjourn

 

Cholesterol and Nanoparticles

We are all familiar, at this point in time, with the concept of "good" (HDL) and "bad" (LDL)cholesterol and with the effects of a build up of "bad" cholesterol on the walls of arteries and other blood vessels. Cardiovascular disease is now the leading cause of death in the United States, ahead of cancer.

According to an article published in late November in the New York Times, research at Northwestern University, under the direction of Drs. C. Shad Thaxton and Chad A. Mirkin, and at the Mount Sinai School of Medicine under the direction of Dr. Willem J.M. Mulder, may lead to new  tools for the diagnosis and treatment of cardiovascular disease.

Drs. Thaxton and Mirkin's work has focused on creating synthetic versions of the HDL (good cholesterol) molecule using gold nanoparticles to replace the fatty core usually found in the HDL molecule. The altered HDL molecule has been demonstrated in a pilot study to be effective in removing plaque build-ups from blood vessels, by absorbing the LDL cholesterol, just as naturally occurring HDL molecules would.

The research at Mt. Sinai has focused on developing HDL-like nanoparticles for use in different types of imaging; gold nanocrystals were most effective when used in computer tomography while iron oxide nanocrystals were more effective with MRIs. The goal of Dr. Mulder's research is to improve the imaging of hardening of the arteries due to the build-up of plaques

The potential for using the HDL-nanoparticles as treatment for cardiovascular disease, according to Dr. William O'Neill, Executive Dean for Clinical Affairs at the Miller School of Medicine at the University of Miami, "Could revolutionize cardiology".

However, as both Dr. Andre Nel, Director of the Center for Environmental Implications of Nanotechnology at UCLA and Professor Vincent M. Rotello a the University of Massachusetts at Amherst, caution, further study on the possible effects of nanoparticle accumulation in the body need to be done before wide spread use the nano-HDL in treatment for cardiovascular disease, along with exercise, diet changes etc can occur.

EPA to Reverse Position on 'Existing' Nanomaterials

Last September we predicted that sometime in 2010 EPA would reverse its "distinct molecular identity" approach to determining when and whether nanoscale materials are considered New Chemical Substances requiring premanufacturing notice and approval under the Toxic Substances Control Act (TSCA).   We have been advising clients accordingly. 

Inside EPA is now reporting that "EPA toxics chief Steve Owens" . . . "is expected to announce the shift Feb. 5."

Thus, tomorrow should be an interesting day in nano-regulatory-land.  We will provide our readers with a detailed analysis should EPA in fact reverse itself on this important issue.  Stay tuned . . .

The Nanotechnology Education Act

The Nanotechnology Education Act (H.R. 4502), was introduced early last week by Rep. David Wu (D-1st-OR) and co-sponsored by Rep. Daniel Lipinski (D-3rd-Ill). The bill has as it's purpose the establishment of a grant program aimed at helping secondary schools, colleges and universities to established and improve nanotechnology education programs and facilities.

The bill notes that nanotechnology "is generating scientific and technological breakthroughs that will benefit society by improving the way many things are produced" and that

Nanotechnology is likely to have a significant, positive impact on the security, economic well-being, and health of Americans as fields related to nanotechnology expand.

the bill announces its formidable goal:

In order to maximize the benefits of nanotechnology to individuals in the United States, the United States must maintain world leadership in the field, including nanoscience and microtechnology, in the face of determined competition from other nations.

To maintain that level of world leadership

the United States must make a long-term investment in educating United States students in secondary schools and institutions of higher education, so that the students are able to conduct nanoscience research and develop and commercialize nanotechnology applications.

Preparing United States students for careers in nanotechnology, including nanoscience, requires that the students have access to the necessary scientific tools, including scanning electron microscopes designed for teaching, and requires training to enable teachers and professors to use those tools in the classroom and the laboratory.

H.R. 4502 states it's purpose:

is to strengthen the capacity of United States secondary schools and institutions of higher education to prepare students for careers in nanotechnology by providing grants to those schools and institutions to provide the tools necessary for such preparation.

The Director of the National Science Foundation would be directed to "establish a nanotechnology in the schools program". To support the program, "the director shall award grants of not more than $400,000 to eligible institutions". The bill would define "eligible institutions" very broadly and would include:

1) public, private, parochial and charter schools offering one or more advanced placement science courses,

2) community colleges,

3) four year institutions of higher learning (colleges and universities), and

4) "informal learning science and technology centers". The bill does not define these informal centers any further, but this may be clarified and defined further in a committee mark-up session.

Grant funds would be used for

1) the acquisition of equipment and software for use in classrooms

2) to develop and provide educational services; that is, it would be used by teachers and other instructors to develop classes in nanotechnology

3) to pay for teacher education in nanotechnology

Equipment and software purchased with grant funds by colleges and universities would be required by the bill to be used primarily by undergraduate programs and would also be required to be mostly made in the United States.

The Director of the NSF, no later than six months following passage of HR 4502 and it's being signed into law, would need to establish the process and procedures for eligible institutions to apply for the grants. The procedures, like all other procedures for applying for government grants, would need to be published in the Federal Register and commented on by the public before going into effect. Although the bill doesn't state it, the procedures would probably also be posted to a government website for downloading. In selecting recipients for these grants, the Director would

(1) select geographically diverse institutions; grants could not all be given to institutions in one area, for example, schools in New England or California. The grants would need to be spread around the United States.

2) The Director of NSF would be required to encourage the applications of Historically Black Colleges and Universities and minority institutions as defined by section 365 of the Higher Education Act of 1965 (20 U.S.C. 1067k).

3) Select recipients located in states participating in the Experimental Program to Stimulate Competitive Research.

Institutions receiving these grants would need to raise funds equal to 1/4 of the grant amount. And, if the grant exceeds $100,000, the institution would need to wait for 2 years before it could apply for another grant. Each institution would be required to submit a report to the Director of the NSF no later than one year after the grant was awarded regarding its use of grant funds. Every three years, the Director would, on the basis of these reports, evaluate the program, assessing both short and long term impacts of activities supported by the grants. No later than six months after the evaluation, the Director would submit a report to Congress - in its current form, the bill doesnot specify which committee or committees the report would be submitted to. Again, this is something that may be clarified in a committee mark-up session. The Director's report would contain "recommendations concerning the continued need for Federal support of the program. . . ."

HR 4502 authorizes an appropriation of $40 million for FY 2011 and necessary funds for 2012-2014. The bill has been assigned to the House Committee on Science and Technology. No hearings have been scheduled.

To date, only a handful of colleges and universities offer courses or degree programs in nanotechnology, leading to a shortage of trained workers available for the jobs that are and will be created in nanoindustries. The grants that the Nanotechnology Education Act would distribute would represent an investment in preparing a trained workforce capable of stepping into those jobs.

It should be noted, however, that the bill is being introduced against the shadow of President' Obama's statement in in State of the Union speech to freeze all discretionary spending by the federal government for three years:

Starting in 2011, we are prepared to freeze government spending for three years.  Spending related to our national security, Medicare, Medicaid, and Social Security will not be affected.  But all other discretionary government programs will.  Like any cash-strapped family, we will work within a budget to invest in what we need and sacrifice what we don't.  And if I have to enforce this discipline by veto, I will. 

As with other nanotechnology related legislation filed during the 111th Congress, we'll monitor HR 4502's progress and provide updates.