Targeting Tumors

Many of us, at sometime or another, have lost a friend, a colleague, a loved or a family member to some form of cancer. Many of us have experienced first hand the limits of surgery leaving behind tumor cells or chemotherapy or radiation therapy, which kill the cancer cells while weakening a patients immune system, leaving them vulnerable to secondary infections. Many of us, both those who have lost someone and the surgeons, oncologists and nurses who deal with cancer daily, have wished for some treatment or procedure that would not have the side effects of chemotherapy or radiation therapy.

Science Daily, earlier this month, carried an article, "Targeting Tumors Using Tiny  Gold Particles", about the research work done by Geoffrey von Maltzahn and Sangeeta Bhatia in using gold nanorods to kill tumors using heat. While the heat would kill or weaken the cancer cells, the side effects appear to be minimal, at least in the lab mice that have received the nanorods. At this time, no human trials have been conducted or scheduled.

Use of gold nanorods, either to detect cancer cells left behind by surgery or as a supplement to more conventional treatments or as treatments in themselves, is probably a long way down the road at this point, but such research does provide something that a diagnosis of cancer leaves in short supply.

Hope.

International Approaches to the Regulatory Governance of Nanotechnology

"How have Canada and other jurisdictions reacted to the recent emergence of nanotechnology-based products in the marketplace (and what is the current state of affairs)?"

That was the question that the Carlton University Regulatory Governance Initiative posed. To answer it, Jennifer Pelley and Marc Saner produced "International Approaches to the Regulatory Governance of Nanotechnology", which examines how Canada, the United States, the United Kingdom, the EU, and Australia, arrived at their regulatory policies affecting nanotechnology, summarizing the policy papers that informed those decisions, and looking at the external pressures on those governments from industry, unions, consumers, etc.

The report makes for very dry reading, but its a good reference source and worth reading. Just make sure you have a large cup of strong coffee nearby.

One hundred nanoparticles on the wall, one hundred nanoparticles, you take one down . . . .

 As nanotechnology comes to be used on a wider basis in industry, engineered nanoparticles will also begin to be produced in ever greater numbers. Given the possibility that nanoparticles, by their nature, will interact with the environment, humans, animals, and plant life differently that the more bulky forms used in industry now, estimating how many nanoparticles there are has begun to take on greater importance.

"Estimates of Upper Bounds and Trends in Nano-TiO2 Production as a Basis for Exposure Assessment" published online by Environmental Science and Technology, (for a short summary of the paper, please read "Engineers attempt to count nanoparticles in the environment" from R&D Magazine), tries to estimate the current and future production of Nano-TiO2 particles.

While recent studies have estimated environmental TiO2 exposure based on release from end use life cycles. . .  our approach looks further upstream in the life cycle to create upper limits of nano-TiO2 exposure, identifying how much nano-TiO2 may be produced prior to incorporation in end use products. Three pieces of information are necessary to project sources of nano-TiO2 exposure over time: current nano-Ti)2 production volumes must be know to proviade a baseline or y-intercept of our projection function; the maximum potential production volume is considered here as the total TiO2 market, . . . and the growth rate over time (slope) must be estimated to describe how the production magnitude might increase from the baseline toward the maximum potential level. This work estimates these values.

The results of this study may be a bit flawed, since the companies that produce, use or import nano-TiO2 treat that information as proprietary.

Why is it important to have an estimate of how much nano-Ti02 and other nanoparticles the environment, workers, and consumers are exposed to?

With the growth of nanotechnology, engineered nanoparticles are produced and incorporated into products and processes across a broad spectrum of industries and will inevitably enter the environment. The novel properties resulting from their nanoscale size . . . may also cause nanomaterials to interact with the environment and living organisms in ways that may differ from their bulk scale counterparts. . . . Assessing the impacts and risks posed by nanomaterials requires estimates of potential environmental exposure to their materials. In turn, an understanding of the variety and physical magnitude of nanomarticle sources is the starting point for estimating environmental exposure to nanomaterials and interpreting exposure predictions for the purposes of formulating possible regulation and risk management strategies. Relevant exposure estimates are particularly urgent for those materials already finding their way into industrial and consumer products.

If the expectations regarding nanotech becoming significantly more prominent in the near future are realized, any potential negative impacts may have enourmous medical, economic, legal and policy related effects. In the face of certain growth and such uncertain effects, it is essential to produce toxicity and exposure risk assessments for nanomaterials, even if they begin as approximations, to frame the issue and understand the size of the potential problem.

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Birmingham's Future

Birmingham, Alabama, was, from the post civil war years when it was founded, until well into the 20th century, noted for being the industrial center of the South, particularly in the production of iron and steel, earning itself the nickname, "The Pittsburgh of the South".

But economic changes and the shifting of steel production to smaller mills or to foreign plants, have affected Birmingham just as they have most other older cities whose local economies centered on heavy industries and the workers who were employed in the mills and factories. Birmingham, already carrying the burden of racial tension and the aftermath of protests in the 1950s, 1960s, and the 1970s, seemed ready to fade into history and endure a slow death.

Or perhaps not.

According to a recent article in the Birmingham News, the city and NanoInk Inc. are forming a plan to develop programs to train students to fill the jobs that will be opening in nanoindustries in the future, which will need trained workers to fill the anticipated 2 million openings expected by 2015, according to the National Science Foundation.

Granted, its a small bit of hope to hang onto, but in a down economy, a small bit of hope is better than no hope at all. And, if Birmingham, which does have a growing share of the medical device production industry, can bounce back, then perhaps other cities, such as my own home city of Baltimore, can shed their industrial pasts and look towards the future with hope.

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Spheres of Influence

The April issue of Environmental Health Perspectives carried an interesting article by Charles W. Schmidt,  "Nanotechnology Related Environment, Health, and Safety Research: Examining the National Strategy". The article looks at what could be a disturbing development, that

Experts in nanotoxicity and risk assessment have become increasingly polarized, represented on one side by the National Research Council (NRC) and on the other by the National Nanotechnology Initiative (NNI).

Schmidt's article notes that this polarization began after the Nanotechnology Environmental And Health Implications (NEHI) Working Group, part of NNI, released Strategy for Nanotechnology Related Environmental Health and Safety Research in February 2008. The report presented the then Bush Administration's agenda for studying nanoparticle hazards and was developed and written after "extensive consultations with regulatory agencies, research organizations, the business community and non-governmental organizations". The report reflected the concerns of the established stakeholders in nanotechnology.

In February 2009, an NRC assembled panel released its own report

. . .  describing what it calls serious short comings in the strategy document. According to the NRC panel . . . the strategy exposes weaknesses in the government's understanding of potential nanotechnology risks today and doesnot adequately address how they will be assessed in the future.

. . . NRC panelists would like to see a National Health based Strategy for nanotechnology research with defined goals, milestones, and mechanisms for assessing progress. . . . The need isn't just to insure the safety of nano-enabled products, but also to avert a public backlash against the technology, which could grow if health risks aren't seen as adequately addressed.

. . . The NNI strategy document - NRC panelists claim - is simply a compendium of federally funded projects without any unifying vision or sense of shared purpose.

An advance copy of the NRC report leaked out to the press in December 2008, leading NNI to post a rebuttal on its website , presenting the strategy document not an implementation plan, "But rather a higher-level description of the inter-agency approach to nanotechnology related EHS research."

One can only hope that the growing divide can be bridged. Both sides have much to contribute to the future growth of nanotechnology and a split into opposing camps serves neither side very well.

The final part of this article turns toward a different, in many ways more worrisome, topic. In January 2008, the EPA launched its nanoscale materials voluntary stewardship program, which urged companies to report information to EPA about their use, manufacture, import, etc of nanoparticles; according to the article, as of January 2009, only 29 companies had responded.

While companies might fear that their trade secrets might be revealed to competitors, it is more likely that what companies are afraid of are potential product liability lawsuits, legitimate or not, that would keep them in court for years (the shadow of asbestos again) and giving information to groups that would use the general public lack of understanding of nanotechnology - to most people, this is still science fiction - to create a climate of fear. At this stage in its development, the nanoindustry might be compared to the nuclear industry from 1950 until the mid-1980s. For the general public in that period, nuclear power was a mysterious thing beyond the non-scientist's ability to understand. For most people, nuclear energy meant only one thing: the power to destroy, personified in the form of Godzilla. Interest groups opposed to the further development of nuclear energy were able to use companies involved in the construction and running of nuclear power plants unwillingness to provide the public with information to create an effective climate of fear and opposition to the point where the industry nearly shut down after 3 Mile Island and Chernobyl.

To avoid this fate

. . .  nanoparticle toxicity data need to be made more widely available to insure public support for the technology.

rather than burying the information in annual reports or SEC filings, such as a 10K or a 10Q, which, while they are great sources of information, are also usually great cures for insomnia.

In an age of calls for greater transparency in both government and business, one can only hope that the nanoindustry will seize the moment and release more information in a form and language that the general public can understand. As someone once observed, sunshine is the best disinfectant.

 

 

Green Building Expo and Get Green Business Conference

On May 19, 2009 -- Porter Wright is a sponsor of the Green Building Expo and Get Green Business Conference at the Nationwide and Ohio Farm Bureau 4-H Center on The Ohio State University Campus in Columbus, Ohio.   The event is presented by Columbus Mayor Michael Coleman’s Green Team and is expected to draw over 1,000 attendees.  The conference will bring together local business leaders to position the region for growth and new opportunities.  In addition to nearly 70 exhibitors, various educational programs will be offered such as “Liability of Building Green – Legal issues facing Building Owners & Design Professionals,” “Green Renovation Strategies – The Audit Process & Implementing your Energy Goals,” and “Economic Stimulus Plan – Update for Green Building Industry & Businesses in Ohio.”  Other programs will include “How to Become a Greenspot,” “Senate Bill 221,” “Energy Efficiency & Conservation,” “Cap & Trade,” and “By-Product Synergy.”  For additional information, please contact Tracy Treon at ttreon@porterwright.com

Nanotechnology Health and Safety Forum -- June 8 - 9, 2009

The Nanotechnology Health and Safety Forum which is being sponsored by Battelle, Porter Wright, University of Washington, University of Oregon, Oregon State University, and several others is taking place on June 8 - 9, 2009 at the Edgewater Hotel in Seattle, Washington.

Keynote speakers include: Dr. Leroy Hood, Co-Founder of the Institute for Systems Biology; Dr. Kenneth Dawson, Director of the Centre for BioNano Interactions; Dr. Justin Teeguarden Senior Research Scientist at Pacific Northwest National Laboratory and recent co-author of the NRC's assessment of the NNI's EHS research strategy; Dr. Vladimir Murashov from NIOSH; Dr. Saber Hussain from the Air Force Research Laboratory; former U.S. Congressman George Nethercutt; and Dr. Robert Tanguay from Oregon State University.

The program has 4 units:  Framing the Unknown; nanoEHS Perspective; Insurance, Nanotechnology, and Risk; and Nanotechnology: The Next Ten Years.

I will be speaking on the Insurance, Nanotechnology, and Risk panel on the second day of the conference along with Steve Knutson from Zurich North America; Walter Andrews from Hunton & Williams; and William E. Barr from Chubb Insurance.

You can sign up for the conference here.  Hope to see you there.

Cobalt Doped Tungsten Carbide Nanoparticles and Mammalian Cells

To achieve harder metals that don't wear down quickly, manufacturers are considering the use of tungsten-carbide nanoparticles and cobalt, which is thought to increase the strength and durability of the finished product.

Unfortunately, as Susanne Bastian et al's article "Toxicity of Tungsten Carbide and Cobalt-Doped Carbide Nanoparticles in Mammalian Cells in Vitro" (Supplemental Material available here), demonstrates, increased exposure to these nanoparticles will, in all likelihood, lead to increased incidences of asthma, other respritory illnesses, and lung cancer among workers.

The good thing about studies like this is that, since nanomanufacturing is still in its infancy, there is time to make the necessary changes to the industrial environment that could lower the potential exposure of workers to these types of nanoparticles.

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Carbon Nanotubes

The April issue of Environmental Health Perspectives carries a short article summarizing a seminar at the 2009 AAAS Annual Meeting titled "Driving Beyond Our Nano-Headlights?". In the summary, there is a brief reference to work done by Vanesa Sanchez, a graduate student at Brown University. The results of her experiment are rather alarming.

Ms. Sanchez work showed that

very low doses of CNTs . . . appeared to cause lesions known as granulomas similar to what occurs with asbestos fibers. Moreover, the CNTs formed a cage-like structure that . . .  might promote granuloma formation.

It is too bad that the summary didn't give more space to a study that could have a profound effect on future nanomanufacturing facilities and possible future governmental regulation of the nano-industry.

Uproar among the molecules

This recently published article begins with the assistant secretary of the ACTU, Geoff Fary, once again raising the shadow of asbestos and calling for the Australian government to issue regulations.

To its credit, the article does move beyond Mr. Fary's attempt to create an atmosphere of fear, giving space for other voices to be heard calling for more research and study of the effects of nanoparticles on the environment and human health and to develop regulations and policies in a calmer atmosphere and not to panic.