New Study On Detecting Carbon Nanotubes In Living Organisms

Researchers at Rice University successfully utilized a near-infrared flourescent imaging technique to detect individual carbon nanotubes in fruit flies.  The study, reported here and here, involved an experiment where the researchers fed fruit fly larvae a diet that contained carbon nanotubes.  The flies were then shot with a laser, which excited the nanotubes and allowed them to be viewed using a flourescent technique.   The good news is that the fruit flies apparently survived to adulthood just as well as fruit flies in the control group, and apparently weighed the same as the controls, too.  The study's conclusions about the bioaccumulation of the nanotubes in the fruit flies are interesting:

When the researchers removed and examined tissues from the flies, they found the near-infrared microscope allowed them to see and identify individual nanotubes inside the tissue specimens. The highest concentration of nanotubes was found in the dorsal vessel, which is analogous to a main blood vessel in a mammal. Lesser concentrations were found in the brain, ventral nerve cord, salivary glands, trachea and fat. Based on their assays, the team estimates that only about one in 100 million nanotubes passed through the gut wall and became incorporated into the flies' organs. 

I don't know enough about the anatomy of a fruit fly to fully grasp the significance of these findings, but I find it hopeful that only a tiny fraction of the nanotubes accumulated in the flies' organs, and also find it hopeful that the flies were apparently not harmed by the nanotubes' presence.  One of the researchers quoted in the report, Dr. Bruce Weisman, is a well-known nanotechnology researcher at Rice.

Update:

Thanks to Youtube, we can see a six second video of the carbon nanotubes "lit up" inside the fruit flies here

Europe Big On Nanotech Research and EHS Issues

According to this recent article in the Jerusalem Post, the European Union is the top public financier of nanotechnology:

With €1.4 billion allocated to 550 projects in the field of nanosciences and nanotechnology, the EU's 6th Research Framework Program accounts for one-third of total public funding for nanotechnology and is the world's largest single funding agency worldwide for this field.

The article notes, however, that private funding for nanotechnology research in Europe lags the U.S. and Japan.

The Europeans appear to be taking an integrated approach to nanotechnology safety, by investing €28 million in safety research as part of each of its programs.  Much like in the U.S., European regulators are also exploring whether the EC's environmental, health and safety laws require change to deal with these issues:

The European Commission is currently undertaking a review of existing legislation to see whether the current regulatory framework appropriately addresses health, safety and environmental risks. Moreover, it has taken steps to establish an observatory to provide decision-makers with dynamic assessments of scientific and market developments.

It looks like the U.S. might be moving faster on nanotechnology regulatory issues, so I will be interested to see whether the Europeans take our lead or chart their own course.  So far, they seem to be taking a sensible approach to the problem.  I especially like the integration of safety research into their primary research grants (which, among other benefits, reduces the likelihood that scientists will overstate the results of safety issues in an effort to attract more funding) and the inclusion of private industry in the regulatory process.

Threading the Nano Dermal Penetration Needle

NanoBio Corporation is a University of Michigan spinoff that is currently developing a topical lotion containing a nanoscale antimicrobial agent to treat skin infections.  The company presented data from its phase one FDA clinical trials at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy on September 17 - 20, 2007 in Chicago, Illinois.  The data showed the lotion was able to enter skin through pores and hair follicles, but was too large "to penetrate the tight junctions of the epithelium."  The data also showed the drug was not systemically absorbed.  These results should be of particular interest to those involved in the never-ending nanosuncreen/nanocosmetic EHS debate.
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New Woodrow Wilson Nano Public Opinion Poll

The Woodrow Wilson International Center for Scholars released the results of an August 2007 awareness poll conducted by Peter D. Hart Research regarding public knowledge of potential EHS risks associated with the use of certain nanoscale materials in some applications. Fifty-one percent of the 1,014 respondents were unwilling/unable to judge whether nanotechnology's potential benefits outweigh its potential EHS risks. Eighteen percent said the benefits are likely to exceed potential risks, while only six percent believe the opposite. Interestingly, forty-four percent had a fair or great deal of confidence that businesses would be able to maximize the benefits of nanotechnology while minimizing potential risks.  The survey also inquired regarding foods and food packaging containing nanoscale materials. Most respondents said they needed more information before deciding whether or not they would accept food packaging containing nanoscale materials, while only seven percent said they would currently purchase food "enhanced" with nanotechnology.

We look for nano-food packaging to become the "nano-sunscreen" issue of 2008-2009.
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EPA Finally Issues "Nanosilver" Notice

In response to the Samsung Washing Machine "nanosilver" controversy last year, EPA indicated it would issue a federal notice concerning how it intends to treat silver ion generators under FIFRA. Many urged EPA to use this opportunity to issue a broad proclamation that all products containing nanoscale silver would be required to be registered as pesticides under FIFRA. NanoLawReport believed EPA would issue a significantly narrower ruling.

On Monday, EPA finally published its promised federal notice requiring products that emit silver ions or other antimicrobial substances to be registered as pesticides under FIFRA. EPA was clear that the notice is not intended to regulate nanotechnology as a whole, nor has the Agency even received information suggesting that the Samsung washing machine in question uses nanotechnology. Whether EPA will require other products containing nanosilver to be registered under FIFRA is likely to be decided on a case-by-case basis.

NINE is up and running

You'll recall some time ago, I reported on the National Institute of Nano Engineering that was being housed at Sandia National Labs.  While still in its infancy, NINE is making progress and can now be accessed on its new webpage (102 total hits as of this posting). Continue Reading...

New EPA Nanotechnology Research Plan Forthcoming

The head of EPA's Office of Research & Development recently indicated the agency will release a first draft of a new nanotechnology research plan this fall, building on its previous White Paper released last February. The new plan will apparently outline research needed in (i) fate, transport and exposure; (ii) human health and ecological effects; (iii) risk assessment; and (iv) managing risks through engineering and technology.
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Antimicrobial SWCNTs

Researchers at Yale University who are investigating the potential toxicity of SWCNTs recently announced they observed unique antimicrobial properties of the tested materials. Researchers in the study apparently removed metal contaminants from the SWCNT material to prevent false results, and then found that E. Coli test cells were killed on contact with the SWCNTs. The researchers believe that the SWCNTs' unique shape and small size allowed them to puncture and destroy the E. Coli cells. The scientists preliminary results also indicated MWCNTs are less than toxic than SWCNTs in a lab study.
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Explosive Nanohype

Russia announced it has tested the "father of all bombs," a non-nuclear device that apparently emits shockwaves as powerful as a nuclear weapon. The new weapon is supposed to be four times more powerful than the U.S.'s largest non-nuclear bomb which is pretty powerful -- capable of destroying several city blocks. Russia's bomb is also supposed to be significantly smaller than the U.S. weapon. The key to the bomb's dramatically increased power is an unspecified form of "nanotechnology" that greatly increases the temperature at the epicenter of the bomb's blast. One Russian general has apparently claimed the new bomb is "environmentally friendly" despite its massive destructive qualities. U.S. plaintiffs' attorneys are no doubt taking notes along with the military establishment.
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EPA Studies Metal Oxide Nanoparticles in Drinking Water

The U.S. Environmental Protection Agency is currently evaluating the potential EHS risks associated with nanoparticles in drinking water. The research is being conducted out of EPA's National Health & Environmental Effects Research Laboratory and is specifically focused (for the moment) on metal oxide nanoparticles in drinking water. The research is investigating the potential EHS effects of nanoscale zero-valent iron used for groundwater remediation and nanoscale titanium dioxide used in drinking water purification. The project's first report should be issued by the end of the year, with additional reports on other nanoscale materials over the next few years.
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Marsh Center Looks at Nanorisks

The Marsh Center for Risk Insights focuses on identifying critical global business risks. A June 2007 survey of Fortune 100 executives inquired regarding the amount of preparation they were taking to address potential emerging business risks. Nanotechnology was included among seven other potential risks: natural disasters, terrorist attacks, oil price spikes, global climate change, housing market collapse, access to water, and pandemics. Marsh concluded from the survey that businesses were not adequately preparing for these risks because they did not believe these risks were relevant to their businesses. While preparing for future business risks is commendable (we often counsel clients in this regard), comparing the potential EHS risks posed by nanotechnology with natural disasters, terrorist attacks, and pandemics is irresponsible. It both understates the seriousness of the latter risks, while over stating the potential risks of the former.
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Bill to Provide Consumer Product Safety Commission with Increased Nanotechnology Funding

 

Daniel K. Inouye (D - Hawaii), who chairs the Sentate Commerce Committee, recently introduced a Senate bill which would increase the Consumer Product Safety Commission's funding to address potential nanotechnology EHS issues by "[a]uthorize funding levels for 7 years starting at $80 million in 2009 and increasing at a rate of 10 percent per year through 2015."  For 2008 and 2009, an additional $20 million would be authorized to upgrade CPSC laboratories and $1 million would be authorized to research the safety of nanotechnology in products.  The bill was co-sponsored by Senator Mark Pryor (D - Arkansas) who has been a strong nanotechnology development advocate, and its progress can be tracked online here.
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Pardon Our Dust...

We at the Nanotechnology Law Report apologize for the decrease in number of postings of late.  We are in the process of updating and redesigning our site, and new content has already been moved to the new platform.  Rest assured we are still watching all new developments and issues, and beginning Monday September 24 we will launch Nanotechnology Law Report v. 2.0.  We are excited for this evolution, and hope you will like our new look!

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Nobel Prize in Nanotech? Well, Maybe Not...

A few weeks ago I was intrigued (maybe excited?) about the prospect of a new Nobel Prize in Nanotechnology.   Well, as it turns out, my excitement may have been premature. Continue Reading...